Peptide Libraray

Propeptide 5

General Information

DCTPep ID DCTPep00184

Peptide Name Propeptide 5

Sequence fCYwOXXTKKrPKPfQwFwLXKKLMYPTYLKKfQWAVXHL

Sequence Length 40

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	10.4 % inhibition of cell proliferation at 1 nM	MTT assay	24 h	1
KB	Human papillomavirus-related endocervical adenocarcinoma	10.6 % inhibition of cell proliferation at 1 nM	MTT assay	24 h	1
PTC	Papillary thyroid carcinoma	14.2 % inhibition of cell proliferation at 10 nM	MTT assay	24 h	1
PTC	Papillary thyroid carcinoma	16.5 % inhibition of cell proliferation at 1 nM	MTT assay	24 h	1
PTC	Papillary thyroid carcinoma	16.8 % inhibition of cell proliferation at 100 nM	MTT assay	24 h	1
KB	Human papillomavirus-related endocervical adenocarcinoma	18.2 % inhibition of cell proliferation at 10 nM	MTT assay	24 h	1
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	18.7 % inhibition of cell proliferation at 10 nM	MTT assay	24 h	1
PTC	Papillary thyroid carcinoma	21.7 % inhibition of cell proliferation at 1 µM	MTT assay	24 h	1
Mia PaCa-2	Pancreatic ductal adenocarcinoma	24.2 % inhibition of cell proliferation at 1 nM	MTT assay	24 h	1
PTC	Papillary thyroid carcinoma	27.9 % inhibition of cell proliferation at 10 µM	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	28.2 % inhibition of cell proliferation at 10 nM	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	29.7 % inhibition of cell proliferation at 1 nM	MTT assay	24 h	1
KB	Human papillomavirus-related endocervical adenocarcinoma	30.7 % inhibition of cell proliferation at 100 nM	MTT assay	24 h	1
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	34.7 % inhibition of cell proliferation at 100 nM	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	35.3 % inhibition of cell proliferation at 100 nM	MTT assay	24 h	1
Mia PaCa-2	Pancreatic ductal adenocarcinoma	37.8 % inhibition of cell proliferation at 10 nM	MTT assay	24 h	1
KB	Human papillomavirus-related endocervical adenocarcinoma	43.1 % inhibition of cell proliferation at 1 µM	MTT assay	24 h	1
Mia PaCa-2	Pancreatic ductal adenocarcinoma	48.2 % inhibition of cell proliferation at 100 nM	MTT assay	24 h	1
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	54.3 % inhibition of cell proliferation at 1 µM	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	59.4 % inhibition of cell proliferation at 1 µM	MTT assay	24 h	1
Mia PaCa-2	Pancreatic ductal adenocarcinoma	59.6 % inhibition of cell proliferation at 1 µM	MTT assay	24 h	1
Mia PaCa-2	Pancreatic ductal adenocarcinoma	84.5 % inhibition of cell proliferation at 10 µM	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	85.4 % inhibition of cell proliferation at 10 µM	MTT assay	24 h	1
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	94.5 % inhibition of cell proliferation at 10 µM	MTT assay	24 h	1
KB	Human papillomavirus-related endocervical adenocarcinoma	98.3 % inhibition of cell proliferation at 10 µM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys2<--->X7

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification f=D-Phenylalanine; w=D-Tryptophan; O=Ornithine; X(6/21)==cycloleucine or 1-aminocyclopentane-1-carboxylic acid; X(7)=penicillamine; r=D-Arginine; Aib=2-Aminoisobutyric acid

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17559067

Title Delivering multiple anticancer peptides as a single prodrug using lysyl-lysine as a facile linker

Doi 10.1002/psc.867

Year 2007

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available