vibi G

General Information


DCTPep ID  DCTPep00188

Peptide Name   vibi G

Sequence  GTFPCGESCVFIPCLTSAIGCSCKSKVCYKN

Sequence Length  31

UniProt ID  P85245 

PubChem CID  Not available

Origin  V. biflora

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia IC50=0.96 μM Fluorometric microculture cytotoxicity assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00188

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C139H221N35O42S6

Absent amino acids  DHMQRW

Theoretical pI  8.33

Acidic residues  1

Basic residues  3

Polar residues  17

Molecular weight (Average)  3246.85

Molecular weight (Monoisotopic)  3244.46

Common amino acids  C

Net charge  2

Instability index (II)  37.19

Aliphatic index  59.68

Grand average of hydropathicity (GRAVY)  0.471

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1865
  Abs 0.1% (=1 g/l) 0.574, assuming all pairs of Cys residues form cystines
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.459, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18191970

Title  The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

Doi 10.1016/j.phytochem.2007.10.023

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.