DCTPep ID  DCTPep00195

Peptide Name   mPep1

Sequence  RKAFRWAWRMLKKAAPSITCVR

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  Bovine lactoferrin (Lf-B)

Type  Synthetic peptide

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  mPep1 causes necrotic cell death by destroying cellular membrane structure

PDB ID  Not available

Predicted Structure  DCTPep00195

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -0.350

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 4.110, assuming all pairs of Cys residues form cystines
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 4.110, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 18425992

Title  A lactoferrin-derived peptide with cationic residues concentrated in a region of its helical structure induces necrotic cell death in a leukemic cell line (HL-61)

Doi 10.1002/psc.1039

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available