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a5
General Information
DCTPep ID DCTPep00198
Peptide Name a5
Sequence KAQIRAMECNIL
Sequence Length 12
UniProt ID Not available
PubChem CID 44587505
Origin Cyclin B (285-296)
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C58H104N18O17S2
Absent amino acids DFGHPSTVWY
Theoretical pI 8.22
Acidic residues 1
Basic residues 2
Polar residues 2
Molecular weight (Average) 1389.69
Molecular weight (Monoisotopic) 1388.73
Common amino acids AI
Net charge 1
Instability index (II) 98.45
Aliphatic index 114.17
Grand average of hydropathicity (GRAVY) 0.158
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18656352
Title A novel peptide from alpha5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat(49-57) with cytotoxic and apoptotic effects against human cancer cells
Doi 10.1016/j.bmcl.2008.07.017
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.