Peptide Libraray

PST13-RK

General Information

DCTPep ID DCTPep00200

Peptide Name PST13-RK

Sequence KKKFPWWWPFKKK

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Derivative of tritrpticin

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-361	Breast adenocarcinoma	IC50=80 µg/ml	MTT assay	Not available	1
A549	Lung adenocarcinoma	IC50=90 µg/ml	MTT assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH-3T3 (mouse): IC50=83 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00200

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C97H136N22O14

Absent amino acids ACDEGHILMNQRSTVY

Theoretical pI 10.70

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1834.29

Molecular weight (Monoisotopic) 1833.06

Common amino acids K

Net charge 6

Instability index (II) 25.08

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -1.823

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 8.995

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18815734

Title Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity

Doi 10.1007/s10529-008-9848-5

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available