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di-PST13-RK-C
General Information
DCTPep ID DCTPep00201
Peptide Name di-PST13-RK-C
Sequence KKKFPWWWPFKKKCKKKFPWWWPFKKKC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Derivative of tritrpticin
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-361 | Breast adenocarcinoma | IC50=10 µg/ml | MTT assay | Not available | 1 |
| A549 | Lung adenocarcinoma | IC50=15 µg/ml | MTT assay | Not available | 1 |
| A549 | Lung adenocarcinoma | IC50=17 µg/ml | MTT assay | Not available | 1 |
| MDA-MB-361 | Breast adenocarcinoma | IC50=17 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH-3T3 (mouse): IC50=20 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00201
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C200H280N46O29S2
Absent amino acids ADEGHILMNQRSTVY
Theoretical pI 10.49
Acidic residues 0
Basic residues 12
Polar residues 2
Molecular weight (Average) 3856.83
Molecular weight (Monoisotopic) 3854.13
Common amino acids K
Net charge 12
Instability index (II) 24.36
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -1.514
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 33125
Abs 0.1% (=1 g/l) 8.589, assuming all pairs of Cys residues form cystines
Ext. coefficient 33000
Abs 0.1% (=1 g/l) 8.556, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18815734
Title Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.