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PNC-28
General Information
DCTPep ID DCTPep00203
Peptide Name PNC-28
Sequence ETFSDLWKLL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Antennapedia
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | 100% Cytotoxicity=75μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism PNC-28 may be effective in treating human pancreatic cancer. The penetratin sequence appears to be responsible for the fundamental change in the mechanism of action, inducing rapid necrosis initiated by membrane pore formation.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C60H90N12O17
Absent amino acids ACGHIMNPQRVY
Theoretical pI 4.37
Acidic residues 2
Basic residues 1
Polar residues 2
Molecular weight (Average) 1251.44
Molecular weight (Monoisotopic) 1250.65
Common amino acids L
Net charge -1
Instability index (II) 36.53
Aliphatic index 117.00
Grand average of hydropathicity (GRAVY) 0.090
Half Life
1 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 4.395
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18931881
Title The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.