Peptide Libraray

Temporin-CEb

General Information

DCTPep ID DCTPep00213

Peptide Name Temporin-CEb

Sequence ILPILSLIGGLL

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin skin of the Chinese brown frog, Rana chensinensis

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=56 µM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: LD50=112 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C60H108N12O14

Absent amino acids ACDEFHKMNQRTVWY

Theoretical pI 5.52

Acidic residues 0

Basic residues 0

Polar residues 3

Molecular weight (Average) 1221.59

Molecular weight (Monoisotopic) 1220.81

Common amino acids L

Net charge 0

Instability index (II) 67.6

Aliphatic index 260.00

Grand average of hydropathicity (GRAVY) 2.442

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 19341344

Title Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis

Doi 10.2108/zsj.26.220

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available