Peptide Libraray

Chensinin-1

General Information

DCTPep ID DCTPep00214

Peptide Name Chensinin-1

Sequence SAVGRHGRRFGLRKHRKH

Sequence Length 18

UniProt ID B5A9T1

PubChem CID Not available

Origin skin of the Chinese brown frog, Rana chensinensis

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50>200 µM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: LD50>500 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00214

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C92H155N41O20

Absent amino acids CDEIMNPQTWY

Theoretical pI 12.60

Acidic residues 0

Basic residues 10

Polar residues 4

Molecular weight (Average) 2155.51

Molecular weight (Monoisotopic) 2154.24

Common amino acids R

Net charge 10

Instability index (II) 52.19

Aliphatic index 43.33

Grand average of hydropathicity (GRAVY) -1.628

Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 19341344

Title Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis

Doi 10.2108/zsj.26.220

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available