This work is licensed under a Creative Commons Attribution 4.0 International License.
Malanin chain A
General Information
DCTPep ID DCTPep00215
Peptide Name Malanin chain A
Sequence DYPKLTFTTS
Sequence Length 10
UniProt ID P86600
PubChem CID Not available
Origin Malania oleifera
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=0.15±0.08nM | MTT assay | 72h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=11.20±0.02nM | MTT assay | 72h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=15.80±0.09nM | MTT assay | 72h | 1 |
| PC-12 | Lung papillary adenocarcinoma | IC50=7.71±0.24nM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero: IC50=2.79±0.05nM; MDCK: IC50=3.92±0.01nM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 1172.3
Molecular weight (Monoisotopic) 1171.58
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19341757
Title Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera
Doi 10.1016/j.toxicon.2009.03.024
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.