Malanin chain A

General Information


DCTPep ID  DCTPep00215

Peptide Name   Malanin chain A

Sequence  DYPKLTFTTS

Sequence Length  10

UniProt ID  P86600 

PubChem CID  Not available

Origin  Malania oleifera

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=0.15±0.08nM MTT assay 72h 1
MCF-7 Invasive breast carcinoma of no special type IC50=11.20±0.02nM MTT assay 72h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia IC50=15.80±0.09nM MTT assay 72h 1
PC-12 Lung papillary adenocarcinoma IC50=7.71±0.24nM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Vero: IC50=2.79±0.05nM; MDCK: IC50=3.92±0.01nM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  1172.3

Molecular weight (Monoisotopic)  1171.58

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19341757

Title  Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera

Doi 10.1016/j.toxicon.2009.03.024

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.