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KW5
General Information
DCTPep ID DCTPep00219
Peptide Name KW5
Sequence KAAKKAAKAAKKAAKAAKKAA
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Bovine lactoferrin (Lf-B)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| FEMX-I | Melanoma | IC50=30±3 µM | MTT assay | 30 min | 1 |
| HT-29 | Colon adenocarcinoma | IC50=55±14 µM | MTT assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Peptides induce lysis of cancer cells through interactions with the plasma membrane
Structure Information
PDB ID Not available
Predicted Structure DCTPep00219
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H170N30O22
Absent amino acids CDEFGHILMNPQRSTVWY
Theoretical pI 10.90
Acidic residues 0
Basic residues 9
Polar residues 0
Molecular weight (Average) 2024.53
Molecular weight (Monoisotopic) 2023.31
Common amino acids A
Net charge 9
Instability index (II) 9.52
Aliphatic index 57.14
Grand average of hydropathicity (GRAVY) -0.643
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19527490
Title The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.