Peptide Libraray

Ltc-2a [I7Q]

General Information

DCTPep ID DCTPep00226

Peptide Name Ltc-2a [I7Q]

Sequence GLFGKLQKKFGRKAISYAVKKARGKH

Sequence Length 26

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL3 positive; Chronic myeloid leukemia	EC50=18 µM	Hoechst 33342 and PI assay	3h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis>36 µM

Normal (non-cancerous) Cytotoxicity Human leukocytes: 50% Cell death>36 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00226

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C135H226N42O30

Absent amino acids CDEMNPTW

Theoretical pI 11.33

Acidic residues 0

Basic residues 10

Polar residues 6

Molecular weight (Average) 2917.54

Molecular weight (Monoisotopic) 2915.74

Common amino acids K

Net charge 10

Instability index (II) 17.09

Aliphatic index 67.69

Grand average of hydropathicity (GRAVY) -0.746

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.511

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 19563807

Title N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins

Doi 10.1016/j.febslet.2009.06.044

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available