Peptide Libraray

Psyle A

General Information

DCTPep ID DCTPep00236

Peptide Name Psyle A

Sequence GIACGESCVFLGCFIPGCSCKSKVCYFN

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin Micronesian Plant Psychotria leptothyrsa

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	IC50=26 μM	Nonclonogenic fluorometric microculture cytotoxicity assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00236

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C128H195N31O36S6

Absent amino acids DHMQRTW

Theoretical pI 7.77

Acidic residues 1

Basic residues 2

Polar residues 15

Molecular weight (Average) 2936.5

Molecular weight (Monoisotopic) 2934.27

Common amino acids C

Net charge 1

Instability index (II) 43.02

Aliphatic index 66.07

Grand average of hydropathicity (GRAVY) 0.882

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1865
Abs 0.1% (=1 g/l) 0.635, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.507, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20575512

Title Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa

Doi 10.1021/np9007365

Year 2010

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available