Peptide Libraray

Callyaerin E

General Information

DCTPep ID DCTPep00239

Peptide Name Callyaerin E

Sequence LPFFPPVXPIIG

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Callyspongia aerizusa

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
L5178Y	Mouse leukemia	ED50=0.39µM	MTT assay	72h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	ED50=3.4µM	MTT assay	72h	1
PC-12	Lung papillary adenocarcinoma	ED50=3.8µM	MTT assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond SMB: Leu1<--->X(8)

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification X=Daa

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20599387

Title Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

Doi 10.1016/j.bmc.2010.06.012

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available