Callyaerin E

General Information


DCTPep ID  DCTPep00239

Peptide Name   Callyaerin E

Sequence  LPFFPPVXPIIG

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Callyspongia aerizusa

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
L5178Y Mouse leukemia ED50=0.39µM MTT assay 72h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma ED50=3.4µM MTT assay 72h 1
PC-12 Lung papillary adenocarcinoma ED50=3.8µM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  SMB: Leu1<--->X(8)

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=Daa

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20599387

Title  Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

Doi 10.1016/j.bmc.2010.06.012

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.