This work is licensed under a Creative Commons Attribution 4.0 International License.
Peptide-20
General Information
DCTPep ID DCTPep00244
Peptide Name Peptide-20
Sequence CSSRTMHHC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A2058 | Amelanotic melanoma | 30% viablity=100 µM | MTT assay | 48 h | 1 |
| SK-MEL-28 | Cutaneous melanoma | 35-40% viablity=100 µM | MTT assay | 48 h | 1 |
| B16-F10 | Mouse melanoma | 50% viablity=100 µM | MTT assay | 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 50% viablity=100 µM | MTT assay | 48 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | 55% viablity=100 µM | MTT assay | 48 h | 1 |
| SK-MEL-25 | Melanoma | 55-60% viablity=100 µM | MTT assay | 48 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | 90% viablity=100 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target cadherin constituent at the tumor cell surface
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C39H64N16O13S3
Absent amino acids ADEFGIKLNPQVWY
Theoretical pI 8.09
Acidic residues 0
Basic residues 3
Polar residues 5
Molecular weight (Average) 1061.22
Molecular weight (Monoisotopic) 1060.4
Common amino acids CHS
Net charge 3
Instability index (II) 115.33
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -0.700
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.118, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20802991
Title A novel melanoma-targeting peptide screened by phage display exhibits antitumor activity
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.