Peptide Libraray

Dex-(KW)3

General Information

DCTPep ID DCTPep00245

Peptide Name Dex-(KW)3

Sequence KWKWKW

Sequence Length 6

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	35-40% viablity=10 µM	MTT assay	Not available	1
PC-3	Prostate carcinoma	60% viablity=10 µM	MTT assay	Not available	1

Hemolytic Activity rabbit red blood cell: hemolysis=1.9±0.2%

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C51H68N12O7

Absent amino acids ACDEFGHILMNPQRSTVY

Theoretical pI 10.30

Acidic residues 0

Basic residues 3

Polar residues 0

Molecular weight (Average) 961.18

Molecular weight (Monoisotopic) 960.53

Common amino acids KW

Net charge 3

Instability index (II) 8.33

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -2.400

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 17.166

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20964334

Title Synthesis, characterization, and thermodynamic study of a polyvalent lytic peptide-polymer conjugate as novel anticancer agent

Doi 10.1021/bc1002899

Year 2010

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available