This work is licensed under a Creative Commons Attribution 4.0 International License.
Buforin II
General Information
DCTPep ID DCTPep00262
Peptide Name Buforin II
Sequence TRSSRAGLQFPVGRVHRLLRK
Sequence Length 21
UniProt ID P55897 P59890 P0DQL2 C0HJQ3 P06897 P02264 Q7ZUY3 Q96KK5 Q6GM86 P0C0S8 Q99878
PubChem CID 16136511
Origin Bufo Bufo Gargarizans
Type Native peptide
Classification
Antiangiogenic
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 5% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00262
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C106H184N40O26
Absent amino acids CDEIMNWY
Theoretical pI 12.60
Acidic residues 0
Basic residues 7
Polar residues 5
Molecular weight (Average) 2434.88
Molecular weight (Monoisotopic) 2433.43
Common amino acids R
Net charge 7
Instability index (II) 84.2
Aliphatic index 88.10
Grand average of hydropathicity (GRAVY) -0.638
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.