This work is licensed under a Creative Commons Attribution 4.0 International License.
Demegen P-113
General Information
DCTPep ID DCTPep00264
Peptide Name Demegen P-113
Sequence AKRHHGYKRKFH
Sequence Length 12
UniProt ID Not available
PubChem CID 71587612
Origin Amphibian skin peptide
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 15% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H109N27O14
Absent amino acids CDEILMNPQSTVW
Theoretical pI 11.17
Acidic residues 0
Basic residues 8
Polar residues 2
Molecular weight (Average) 1564.82
Molecular weight (Monoisotopic) 1563.86
Common amino acids HK
Net charge 8
Instability index (II) 63.83
Aliphatic index 8.33
Grand average of hydropathicity (GRAVY) -2.283
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.952
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.