This work is licensed under a Creative Commons Attribution 4.0 International License.
OmigaNAn MBI-226
General Information
DCTPep ID DCTPep00265
Peptide Name OmigaNAn MBI-226
Sequence ILRWPWWPWRRK
Sequence Length 12
UniProt ID Not available
PubChem CID 16131446
Origin Helical peptide with a predominance of one or more amino acids tryptophane-rich
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 27% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C90H126N26O13
Absent amino acids ACDEFGHMNQSTVY
Theoretical pI 12.30
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1780.16
Molecular weight (Monoisotopic) 1779
Common amino acids W
Net charge 4
Instability index (II) 131.93
Aliphatic index 65.00
Grand average of hydropathicity (GRAVY) -1.325
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 12.358
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.