OmigaNAn MBI-226

General Information


DCTPep ID  DCTPep00265

Peptide Name   OmigaNAn MBI-226

Sequence  ILRWPWWPWRRK

Sequence Length  12

UniProt ID  Not available

PubChem CID  16131446 

Origin  Helical peptide with a predominance of one or more amino acids tryptophane-rich

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia 27% Cytotoxicity at 0.5 µg/ml MTT assay 6 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C90H126N26O13

Absent amino acids  ACDEFGHMNQSTVY

Theoretical pI  12.30

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1780.16

Molecular weight (Monoisotopic)  1779

Common amino acids  W

Net charge  4

Instability index (II)  131.93

Aliphatic index  65.00

Grand average of hydropathicity (GRAVY)  -1.325

Half Life 
  20 hours (mammalian reticulocytes, in vitro).
  30 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 22000
  Abs 0.1% (=1 g/l) 12.358

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21403917

Title  Antitumor activity of antimicrobial peptides against U937 histiocytic cell line

Doi Not available

Year  2011

Literature 2

Pubmed ID 8573171

Title  A novel antimicrobial peptide from Bufo bufo gargarizans

Doi 10.1006/bbrc.1996.0071

Year  1996

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.