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Protegrin 1
General Information
DCTPep ID DCTPep00267
Peptide Name Protegrin 1
Sequence RGGRLCYCRRRFCVCVGR
Sequence Length 18
UniProt ID P32194
PubChem CID Not available
Origin Alpha helical peptide without cysteines
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 61% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1PG1
Predicted Structure DCTPep00267
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C88H150N36O20S4
Absent amino acids ADEHIKMNPQSTW
Theoretical pI 10.66
Acidic residues 0
Basic residues 6
Polar residues 8
Molecular weight (Average) 2160.63
Molecular weight (Monoisotopic) 2159.07
Common amino acids R
Net charge 6
Instability index (II) 62.13
Aliphatic index 53.89
Grand average of hydropathicity (GRAVY) -0.250
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1740
Abs 0.1% (=1 g/l) 0.805, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.690, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.