Peptide Libraray

Temporin A

General Information

DCTPep ID DCTPep00268

Peptide Name Temporin A

Sequence FLPLIGRVLSGIL

Sequence Length 13

UniProt ID Not available

PubChem CID 9920205

Origin Frog Rana temporaria

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	15% Cytotoxicity at 0.5 µg/ml	MTT assay	6 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00268

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C68H116N16O15

Absent amino acids ACDEHKMNQTWY

Theoretical pI 9.75

Acidic residues 0

Basic residues 1

Polar residues 3

Molecular weight (Average) 1397.77

Molecular weight (Monoisotopic) 1396.88

Common amino acids L

Net charge 1

Instability index (II) 32.33

Aliphatic index 202.31

Grand average of hydropathicity (GRAVY) 1.808

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21403917

Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line

Doi Not available

Year 2011

Literature 2

Pubmed ID 8573171

Title A novel antimicrobial peptide from Bufo bufo gargarizans

Doi 10.1006/bbrc.1996.0071

Year 1996

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available