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DI
General Information
DCTPep ID DCTPep00269
Peptide Name DI
Sequence LTFEHYWAQLTS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin E3 ubiquitin-protein ligase
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Affect cell cycle
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| -- | -- | IC50 for MDM2=0.29 µM | ELISA assay | Not available | 1 |
| -- | -- | IC50 for MDMX-p53=1.6 µM | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism Inhibits MDM2-p53 Interaction
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H98N16O20
Absent amino acids CDGIKMNPRV
Theoretical pI 5.24
Acidic residues 1
Basic residues 1
Polar residues 4
Molecular weight (Average) 1495.65
Molecular weight (Monoisotopic) 1494.71
Common amino acids LT
Net charge 0
Instability index (II) 28.62
Aliphatic index 73.33
Grand average of hydropathicity (GRAVY) -0.200
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.674
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21423613
Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction
Doi 10.1371/journal.pone.0017898
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.