DI

General Information


DCTPep ID  DCTPep00269

Peptide Name   DI

Sequence  LTFEHYWAQLTS

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  E3 ubiquitin-protein ligase

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides Affect cell cycle



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
-- -- IC50 for MDM2=0.29 µM ELISA assay Not available 1
-- -- IC50 for MDMX-p53=1.6 µM ELISA assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2

Affinity  Not available

Mechanism  Inhibits MDM2-p53 Interaction



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C71H98N16O20

Absent amino acids  CDGIKMNPRV

Theoretical pI  5.24

Acidic residues  1

Basic residues  1

Polar residues  4

Molecular weight (Average)  1495.65

Molecular weight (Monoisotopic)  1494.71

Common amino acids  LT

Net charge  0

Instability index (II)  28.62

Aliphatic index  73.33

Grand average of hydropathicity (GRAVY)  -0.200

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 4.674

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21423613

Title  mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction

Doi 10.1371/journal.pone.0017898

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.