Peptide Libraray

General Information

DCTPep ID DCTPep00270

Peptide Name 3A

Sequence LTAEHYAAQATS

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin E3 ubiquitin-protein ligase

Type Synthetic peptide

Classification

Cancer targeted peptides Affect cell cycle

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
--	--	IC50 for MDM2>100 µM	ELISA assay	Not available	1
--	--	IC50 for MDMX-p53>100 µM	ELISA assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target MDM2

Affinity Not available

Mechanism Inhibits MDM2-p53 Interaction

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C54H83N15O20

Absent amino acids CDFGIKMNPRVW

Theoretical pI 5.24

Acidic residues 1

Basic residues 1

Polar residues 4

Molecular weight (Average) 1262.34

Molecular weight (Monoisotopic) 1261.59

Common amino acids A

Net charge 0

Instability index (II) 59.23

Aliphatic index 65.83

Grand average of hydropathicity (GRAVY) -0.225

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.180

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21423613

Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction

Doi 10.1371/journal.pone.0017898

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available