Peptide Libraray

P5317-28

General Information

DCTPep ID DCTPep00271

Peptide Name P5317-28

Sequence QETFSDLWKLLP

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin E3 ubiquitin-protein ligase

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Affect cell cycle

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
--	--	IC50 for MDM2=4.7 µM	ELISA assay	Not available	1
--	--	IC50 for MDMX-p53=30 µM	ELISA assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target MDM2

Affinity Not available

Mechanism Inhibits MDM2-p53 Interaction

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C70H105N15O20

Absent amino acids ACGHIMNRVY

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 2

Molecular weight (Average) 1476.69

Molecular weight (Monoisotopic) 1475.77

Common amino acids L

Net charge -1

Instability index (II) 64.21

Aliphatic index 97.50

Grand average of hydropathicity (GRAVY) -0.350

Half Life
0.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.725

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21423613

Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction

Doi 10.1371/journal.pone.0017898

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available