MIP(W7A)

General Information


DCTPep ID  DCTPep00274

Peptide Name   MIP(W7A)

Sequence  PRFWEYALRLME

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  E3 ubiquitin-protein ligase

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Affect cell cycle



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
-- -- IC50 for MDM2>100 µM ELISA assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2

Affinity  Not available

Mechanism  Inhibits MDM2-p53 Interaction



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C76H111N19O18S1

Absent amino acids  CDGHIKNQSTV

Theoretical pI  6.57

Acidic residues  2

Basic residues  2

Polar residues  1

Molecular weight (Average)  1610.89

Molecular weight (Monoisotopic)  1609.81

Common amino acids  ELR

Net charge  0

Instability index (II)  38.67

Aliphatic index  73.33

Grand average of hydropathicity (GRAVY)  -0.475

Half Life 
  >20 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  ? (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 4.339

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21423613

Title  mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction

Doi 10.1371/journal.pone.0017898

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.