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MIP(W7A)
General Information
DCTPep ID DCTPep00274
Peptide Name MIP(W7A)
Sequence PRFWEYALRLME
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin E3 ubiquitin-protein ligase
Type Synthetic peptide
Classification
Cancer targeted peptides Affect cell cycle
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| -- | -- | IC50 for MDM2>100 µM | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism Inhibits MDM2-p53 Interaction
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C76H111N19O18S1
Absent amino acids CDGHIKNQSTV
Theoretical pI 6.57
Acidic residues 2
Basic residues 2
Polar residues 1
Molecular weight (Average) 1610.89
Molecular weight (Monoisotopic) 1609.81
Common amino acids ELR
Net charge 0
Instability index (II) 38.67
Aliphatic index 73.33
Grand average of hydropathicity (GRAVY) -0.475
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.339
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21423613
Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction
Doi 10.1371/journal.pone.0017898
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.