Peptide Libraray

MIP(R9A)

General Information

DCTPep ID DCTPep00275

Peptide Name MIP(R9A)

Sequence PRFWEYWLALME

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin E3 ubiquitin-protein ligase

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Affect cell cycle

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
--	--	IC50 for MDM2=0.02 µM	ELISA assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target MDM2

Affinity Not available

Mechanism Inhibits MDM2-p53 Interaction

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C81H109N17O18S1

Absent amino acids CDGHIKNQSTV

Theoretical pI 4.53

Acidic residues 2

Basic residues 1

Polar residues 1

Molecular weight (Average) 1640.92

Molecular weight (Monoisotopic) 1639.79

Common amino acids ELW

Net charge -1

Instability index (II) 4.52

Aliphatic index 73.33

Grand average of hydropathicity (GRAVY) -0.175

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 12490
Abs 0.1% (=1 g/l) 7.612

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21423613

Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction

Doi 10.1371/journal.pone.0017898

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available