Peptide Libraray

Vaby D(4)

General Information

DCTPep ID DCTPep00280

Peptide Name Vaby D(4)

Sequence GLPVCGETCFGGTCNTPGCTCDPWPVCTRN

Sequence Length 30

UniProt ID Not available

PubChem CID Not available

Origin Viola abyssinica of the Ethiopian Highlands

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	IC50=2.6 μM	Fluorometric microculture cytotoxicity assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00280

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C127H194N36O42S6

Absent amino acids AHIKMQSY

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 18

Molecular weight (Average) 3089.51

Molecular weight (Monoisotopic) 3087.25

Common amino acids C

Net charge -1

Instability index (II) 56.17

Aliphatic index 32.33

Grand average of hydropathicity (GRAVY) -0.043

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5875
Abs 0.1% (=1 g/l) 1.902, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.780, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21434649

Title Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands

Doi 10.1021/np100790f

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available