NRC-19
General Information
DCTPep ID DCTPep00301
Peptide Name NRC-19
Sequence FLGLLFHGVHHVGKWIHGLIHGHH
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | 50% Cell death=32 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=16 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: >10% Killing=5 µg/ml (4, 28, 52hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00301
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C133H190N40O25
Absent amino acids ACDEMNPQRSTY
Theoretical pI 8.80
Acidic residues 0
Basic residues 8
Polar residues 5
Molecular weight (Average) 2749.22
Molecular weight (Monoisotopic) 2747.48
Common amino acids H
Net charge 8
Instability index (II) -0.17
Aliphatic index 121.67
Grand average of hydropathicity (GRAVY) 0.375
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.001
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available