NRC-18

General Information


DCTPep ID  DCTPep00307

Peptide Name   NRC-18

Sequence  GWKKWFTKGERLSQRHFA

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia 50% Cell death>128 µg/ml MTT assay 2h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis>256 µg/ml

Normal (non-cancerous) Cytotoxicity  Zebrafish embryos: No Killing

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00307

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C106H156N32O24

Absent amino acids  CDIMNPVY

Theoretical pI  11.10

Acidic residues  1

Basic residues  6

Polar residues  4

Molecular weight (Average)  2262.6

Molecular weight (Monoisotopic)  2261.2

Common amino acids  K

Net charge  5

Instability index (II)  23.03

Aliphatic index  27.22

Grand average of hydropathicity (GRAVY)  -1.322

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 4.862

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21729875

Title  The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents

Doi 10.1242/dmm.007310

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.