This work is licensed under a Creative Commons Attribution 4.0 International License.
Cr-AcACP1
General Information
DCTPep ID DCTPep00315
Peptide Name Cr-AcACP1
Sequence AWXLFDDGV
Sequence Length 9
UniProt ID B3EWE7
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Proliferation inhibition
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | IC50=0.8 mM | MTT assay | 72 h | 1 |
| HCT 15 | Colon adenocarcinoma | IC50=1.0 mM | MTT assay | 72 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=1 mM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=4 mM
Target DNA
Affinity Not available
Mechanism Proapoptosis
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification X=Lys-Acetylation (Lysine with acetylation side group)
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21882228
Title Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3239
This work is licensed under a Creative Commons Attribution 4.0 International License.