This work is licensed under a Creative Commons Attribution 4.0 International License.
p776
General Information
DCTPep ID DCTPep00317
Peptide Name p776
Sequence GVGSPYVSRLLGICL
Sequence Length 15
UniProt ID P04626 O18735 P06494 P70424
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Disrupting tumor-mediated mechanisms suppressing host immunity
Structure Information
PDB ID Not available
Predicted Structure DCTPep00317
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C69H116N18O19S1
Absent amino acids ADEFHKMNQTW
Theoretical pI 8.22
Acidic residues 0
Basic residues 1
Polar residues 7
Molecular weight (Average) 1533.85
Molecular weight (Monoisotopic) 1532.84
Common amino acids GL
Net charge 1
Instability index (II) 52.99
Aliphatic index 142.67
Grand average of hydropathicity (GRAVY) 1.107
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.971, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.971, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21928125
Title Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.