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p85
General Information
DCTPep ID DCTPep00318
Peptide Name p85
Sequence LIAHNQVRQV
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Disrupting tumor-mediated mechanisms suppressing host immunity
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C51H88N18O14
Absent amino acids CDEFGKMPSTWY
Theoretical pI 9.76
Acidic residues 0
Basic residues 2
Polar residues 1
Molecular weight (Average) 1177.37
Molecular weight (Monoisotopic) 1176.67
Common amino acids QV
Net charge 2
Instability index (II) 20.83
Aliphatic index 146.00
Grand average of hydropathicity (GRAVY) 0.030
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21928125
Title Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.