Cationic Amphiphilic

General Information


DCTPep ID  DCTPep00321

Peptide Name   Cationic Amphiphilic

Sequence  GIIKKIIIKKIIIKKIIIKKI

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  AMP

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia IC50=10 µM WST-1 assay Not available 1
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=4 µM WST-1 assay Not available 1

Hemolytic Activity  Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs

Normal (non-cancerous) Cytotoxicity  NIH 3T3: low toxic

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00321

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C122H233N29O22

Absent amino acids  ACDEFHLMNPQRSTVWY

Theoretical pI  10.85

Acidic residues  0

Basic residues  8

Polar residues  1

Molecular weight (Average)  2458.37

Molecular weight (Monoisotopic)  2456.8

Common amino acids  I

Net charge  8

Instability index (II)  -26.86

Aliphatic index  222.86

Grand average of hydropathicity (GRAVY)  1.067

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21955251

Title  Designed antimicrobial and antitumor peptides with high selectivity

Doi 10.1021/bm201098j

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.