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Cationic Amphiphilic
General Information
DCTPep ID DCTPep00321
Peptide Name Cationic Amphiphilic
Sequence GIIKKIIIKKIIIKKIIIKKI
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | IC50=10 µM | WST-1 assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=4 µM | WST-1 assay | Not available | 1 |
Hemolytic Activity Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs
Normal (non-cancerous) Cytotoxicity NIH 3T3: low toxic
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00321
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H233N29O22
Absent amino acids ACDEFHLMNPQRSTVWY
Theoretical pI 10.85
Acidic residues 0
Basic residues 8
Polar residues 1
Molecular weight (Average) 2458.37
Molecular weight (Monoisotopic) 2456.8
Common amino acids I
Net charge 8
Instability index (II) -26.86
Aliphatic index 222.86
Grand average of hydropathicity (GRAVY) 1.067
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21955251
Title Designed antimicrobial and antitumor peptides with high selectivity
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.