Z2

General Information


DCTPep ID  DCTPep00332

Peptide Name   Z2

Sequence  KAAKKWAKAWKKAAKAWKKAA

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MT-1 Human mammary carcinoma EC50=173 µM MTT assay Not available 1
HT-29 Colon adenocarcinoma EC50>211 µM MTT assay Not available 1
Meth A Mouse fibrosarcoma EC50>211 µM MTT assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00332

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C114H185N33O22

Absent amino acids  CDEFGHILMNPQRSTVY

Theoretical pI  10.90

Acidic residues  0

Basic residues  9

Polar residues  0

Molecular weight (Average)  2369.93

Molecular weight (Monoisotopic)  2368.44

Common amino acids  AK

Net charge  9

Instability index (II)  2.37

Aliphatic index  42.86

Grand average of hydropathicity (GRAVY)  -1.029

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 16500
  Abs 0.1% (=1 g/l) 6.962

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22057278

Title  Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity

Doi 10.1074/jbc.M111.279281

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.