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LL-III/6
General Information
DCTPep ID DCTPep00382
Peptide Name LL-III/6
Sequence VNWKKILPKIIKVVK
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=6±3 µM | MTT assay | 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50> 40 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Rat erythrocytes: IC50>200 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50> 100 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00382
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C89H156N22O17
Absent amino acids ACDEFGHMQRSTY
Theoretical pI 10.60
Acidic residues 0
Basic residues 5
Polar residues 1
Molecular weight (Average) 1806.35
Molecular weight (Monoisotopic) 1805.2
Common amino acids K
Net charge 5
Instability index (II) 3.54
Aliphatic index 162.00
Grand average of hydropathicity (GRAVY) 0.293
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.045
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.