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SVS-3
General Information
DCTPep ID DCTPep00393
Peptide Name SVS-3
Sequence KVKVKVKVPPTKVKVKVK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50>100µM | MTT assay | 24h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | IC50>100µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50>100µM | MTT assay | 24h | 1 |
| MDA-MB-436 | Invasive breast carcinoma of no special type | IC50>100µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00393
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C97H182N26O20
Absent amino acids ACDEFGHILMNQRSWY
Theoretical pI 10.85
Acidic residues 0
Basic residues 8
Polar residues 1
Molecular weight (Average) 2032.67
Molecular weight (Monoisotopic) 2031.4
Common amino acids K
Net charge 8
Instability index (II) -11.77
Aliphatic index 112.78
Grand average of hydropathicity (GRAVY) -0.317
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22413859
Title Anticancer ?-hairpin peptides: membrane-induced folding triggers activity
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.