This work is licensed under a Creative Commons Attribution 4.0 International License.
Chassatide C11
General Information
DCTPep ID DCTPep00400
Peptide Name Chassatide C11
Sequence IPCGESCVWIPCISGMFGCSCKDKVCYS
Sequence Length 28
UniProt ID C0HKH6
PubChem CID Not available
Origin Chassalia chartacea
Type Native peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=1.2 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: HD50=13.3 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00400
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys19; Cys7<--->Cys21; Cys12<--->Cys26
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H199N31O38S7
Absent amino acids AHLNQRT
Theoretical pI 6.03
Acidic residues 2
Basic residues 2
Polar residues 14
Molecular weight (Average) 3016.6
Molecular weight (Monoisotopic) 3014.26
Common amino acids C
Net charge 0
Instability index (II) 20.91
Aliphatic index 62.50
Grand average of hydropathicity (GRAVY) 0.607
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 7365
Abs 0.1% (=1 g/l) 2.441, assuming all pairs of Cys residues form cystines
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.317, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22467870
Title Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4289
This work is licensed under a Creative Commons Attribution 4.0 International License.