This work is licensed under a Creative Commons Attribution 4.0 International License.
P7
General Information
DCTPep ID DCTPep00403
Peptide Name P7
Sequence PLLQATLGGGS
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin No information found in the references
Type Native peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | IC50=1 µM | WST-1 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Angiogenic factor FGF2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C44H76N12O15
Absent amino acids CDEFHIKMNRVWY
Theoretical pI 5.96
Acidic residues 0
Basic residues 0
Polar residues 5
Molecular weight (Average) 1013.16
Molecular weight (Monoisotopic) 1012.56
Common amino acids GL
Net charge 0
Instability index (II) 61.16
Aliphatic index 115.45
Grand average of hydropathicity (GRAVY) 0.491
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22481251
Title The FGF2-binding peptide P7 inhibits melanoma growth in vitro and in vivo
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.