This work is licensed under a Creative Commons Attribution 4.0 International License.
GA-W3
General Information
DCTPep ID DCTPep00409
Peptide Name GA-W3
Sequence FLGWLFKWAWK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Brevinin-1EMa
Type Native peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SK-MEL-2 | Melanoma | IC50=13.97 µM | MTT assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | IC50=20.36 µM | MTT assay | 72 h | 1 |
| SK-N-DZ | Neuroblastoma | IC50=22.06 µM | MTT assay | 72 h | 1 |
| A498 | Renal cell carcinoma | IC50=22.88 µM | MTT assay | 72 h | 1 |
| MKN45 | Gastric adenocarcinoma | IC50=24.31 µM | MTT assay | 72 h | 1 |
| HCT 116 | Colon carcinoma | IC50=24.63 µM | MTT assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | IC50=46.51 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H104N16O12
Absent amino acids CDEHIMNPQRSTVY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 1
Molecular weight (Average) 1481.81
Molecular weight (Monoisotopic) 1480.8
Common amino acids W
Net charge 2
Instability index (II) 4.2
Aliphatic index 80.00
Grand average of hydropathicity (GRAVY) 0.373
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 11.135
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22644847
Title Anticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.