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N29D
General Information
DCTPep ID DCTPep00412
Peptide Name N29D
Sequence PDEDAINDALNKVCSTGRRQRSICKQLLKK
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SNU-1 | Gastric adenocarcinoma | <100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| SNU-1 | Gastric adenocarcinoma | <40% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | <60% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
| SW480 | Colon adenocarcinoma | >100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| SW480 | Colon adenocarcinoma | 60% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Lyse cancer cells
Structure Information
PDB ID Not available
Predicted Structure DCTPep00412
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C141H247N47O46S2
Absent amino acids FHMWY
Theoretical pI 9.34
Acidic residues 4
Basic residues 7
Polar residues 8
Molecular weight (Average) 3400.92
Molecular weight (Monoisotopic) 3398.79
Common amino acids K
Net charge 3
Instability index (II) 61.03
Aliphatic index 81.33
Grand average of hydropathicity (GRAVY) -0.940
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.037, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22783018
Title Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.