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Peptide P
General Information
DCTPep ID DCTPep00431
Peptide Name Peptide P
Sequence KWKSFLKTFKSLKKTVLHTLLKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Acetylation
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=1.71±0.07 µmol/L | MTS assay | 1 h | 1 |
Hemolytic Activity Human red blood cells: MHC=5.20±0.02 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00431
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C145H242N36O34
Absent amino acids CDEGMNPQRY
Theoretical pI 10.78
Acidic residues 0
Basic residues 8
Polar residues 7
Molecular weight (Average) 3033.74
Molecular weight (Monoisotopic) 3031.83
Common amino acids K
Net charge 8
Instability index (II) 3.29
Aliphatic index 105.00
Grand average of hydropathicity (GRAVY) -0.062
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.813
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22837667
Title Role of helicity on the anticancer mechanism of action of cationic-helical peptides
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.