Peptide Libraray

Latarcin 2a

General Information

DCTPep ID DCTPep00433

Peptide Name Latarcin 2a

Sequence GLFGKLIKKFGRKAISYAVKKARGKH

Sequence Length 26

UniProt ID Q1ELU1

PubChem CID Not available

Origin Central Asian spider, Lachesana tarabaevi

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	EC50=3.3μM	LDH leakage assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID 2G9P

Predicted Structure DCTPep00433

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C136H229N41O29

Absent amino acids CDEMNPQTW

Theoretical pI 11.33

Acidic residues 0

Basic residues 10

Polar residues 6

Molecular weight (Average) 2902.57

Molecular weight (Monoisotopic) 2900.77

Common amino acids K

Net charge 10

Instability index (II) 1.29

Aliphatic index 82.69

Grand average of hydropathicity (GRAVY) -0.438

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.513

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20887768

Title Haemolytic and cytotoxic action of latarcin Ltc2a

Doi 10.1016/j.biochi.2010.09.016

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available