Peptide Libraray

General Information

DCTPep ID DCTPep00439

Peptide Name c8

Sequence KWXKK

Sequence Length 5

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Ramos	Burkitt lymphoma; Burkitt lymphoma	IC50=20±2 μM	MTT assay	Not available	1
Ramos	Burkitt lymphoma; Burkitt lymphoma	IC50=226±21 μM	MTT assay	Not available	1

Hemolytic Activity Human red blood cells: EC50=298 μM

Normal (non-cancerous) Cytotoxicity MRC-5: IC50=53±2 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Lys1<--->Lys5

N-terminal Modification lactam

C-terminal Modification lactam

Other Modification X=p-CF3-Bzl-

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22933412

Title Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid

Doi 10.1002/psc.2441

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available