c2

General Information


DCTPep ID  DCTPep00440

Peptide Name   c2

Sequence  KWXWKK

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Ramos Burkitt lymphoma; Burkitt lymphoma IC50=1.71±0.6 μM MTT assay Not available 1
Ramos Burkitt lymphoma; Burkitt lymphoma IC50=7.9±0.3 μM MTT assay Not available 1

Hemolytic Activity  Human red blood cells: EC50=31 μM

Normal (non-cancerous) Cytotoxicity  MRC-5: IC50=13±1 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Lys1<--->Lys6

N-terminal Modification  lactam

C-terminal Modification  lactam

Other Modification  X=2-Nal-CH2-

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22933412

Title  Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid

Doi 10.1002/psc.2441

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.