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PTP-7a
General Information
DCTPep ID DCTPep00442
Peptide Name PTP-7a
Sequence FLGALFHALSKLL
Sequence Length 13
UniProt ID P80399
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50=28 µM | MTT assay | Not available | 1 |
| PANC-1 | Pancreatic ductal adenocarcinoma | IC50=57 μM | MTT assay | 2 h | 2 |
Hemolytic Activity Human erythrocytes: 6.8% Hemolysis=30 µM
Normal (non-cancerous) Cytotoxicity MCF-10A: IC50=32 μM
Target Not available
Affinity Not available
Mechanism Induced cell tissue damage through a new cell lysis mechanism
Structure Information
PDB ID Not available
Predicted Structure DCTPep00442
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H112N16O15
Absent amino acids CDEIMNPQRTVWY
Theoretical pI 8.76
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1429.77
Molecular weight (Monoisotopic) 1428.85
Common amino acids L
Net charge 2
Instability index (II) -3.83
Aliphatic index 165.38
Grand average of hydropathicity (GRAVY) 1.531
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22934601
Title Peptide Self-Assembly on Cell Membranes to Induce Cell Lysis
Year 2012
Literature 2
Pubmed ID 22526264
Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4524
This work is licensed under a Creative Commons Attribution 4.0 International License.