Peptide Libraray

Adenoregulin (DRS B2)

General Information

DCTPep ID DCTPep00446

Peptide Name Adenoregulin (DRS B2)

Sequence GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV

Sequence Length 33

UniProt ID Not available

PubChem CID Not available

Origin South American frog Phyllomedusa bicolor

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
LNCaP	Prostate carcinoma	GI50=0.31±0.15 µM	LDH leakage assay	24 h	1
DU145	Prostate carcinoma	GI50=0.91±0.04 µM	LDH leakage assay	24 h	1
PC-3	Prostate carcinoma	GI50=1.24±0.23 µM	LDH leakage assay	24 h	1
Raji	EBV-related Burkitt lymphoma; Burkitt lymphoma	GI50=2.57±0.75 µM	LDH leakage assay	24 h	1
MDA-MB-231	Breast adenocarcinoma	GI50=8.06±0.50 µM	LDH leakage assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Drs B2 does not act by apoptosis but possibly by necrosis,antitumor and angiostatic activities

Structure Information

PDB ID Not available

Predicted Structure DCTPep00446

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C142H242N40O42

Absent amino acids CDFHMNPQRTY

Theoretical pI 9.70

Acidic residues 3

Basic residues 6

Polar residues 6

Molecular weight (Average) 3181.73

Molecular weight (Monoisotopic) 3179.8

Common amino acids A

Net charge 3

Instability index (II) 7.27

Aliphatic index 95.15

Grand average of hydropathicity (GRAVY) 0.197

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.729

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23028527

Title Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2

Doi 10.1371/journal.pone.0044351

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available