This work is licensed under a Creative Commons Attribution 4.0 International License.
(RW)3
General Information
DCTPep ID DCTPep00448
Peptide Name (RW)3
Sequence RWRWRW
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | IC50=132±12µM | Resazurin assay | 48h | 1 |
| HepG2 | Hepatoblastoma | IC50=143±21µM | Resazurin assay | 48h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=159±7µM | Resazurin assay | 48h | 1 |
Hemolytic Activity Sheep erythrocytes: 50% Hemolysis=210 µM; Human erythrocytes: 17% Hemolysis=333 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C51H68N18O7
Absent amino acids ACDEFGHIKLMNPQSTVY
Theoretical pI 12.30
Acidic residues 0
Basic residues 3
Polar residues 0
Molecular weight (Average) 1045.22
Molecular weight (Monoisotopic) 1044.55
Common amino acids RW
Net charge 3
Instability index (II) 294.73
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -2.700
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 15.786
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23209509
Title Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups
Year 2012
Literature 2
Pubmed ID 17145799
Title Length effects in antimicrobial peptides of the (RW)n series
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.