This work is licensed under a Creative Commons Attribution 4.0 International License.
Alliumin
General Information
DCTPep ID DCTPep00449
Peptide Name Alliumin
Sequence DDFLCAGGCL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Allium sativum
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| L1210 | Mouse leukemia | IC50=8.33 µM | Radioactive precursor assay | 48h | 1 |
| HepG2 | Hepatoblastoma | NA at 40 µM | Radioactive precursor assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C42H64N10O15S2
Absent amino acids EHIKMNPQRSTVWY
Theoretical pI 3.56
Acidic residues 2
Basic residues 0
Polar residues 4
Molecular weight (Average) 1013.15
Molecular weight (Monoisotopic) 1012.4
Common amino acids CDGL
Net charge -2
Instability index (II) 33.06
Aliphatic index 88.00
Grand average of hydropathicity (GRAVY) 0.940
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.123, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23269800
Title Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.