Peptide Libraray

Pardaxin-6

General Information

DCTPep ID DCTPep00455

Peptide Name Pardaxin-6

Sequence GFFALIPKIISSPLFKTLLSAVGSALS

Sequence Length 27

UniProt ID P81865 P81862 P81861

PubChem CID Not available

Origin Epinephelus nebulosus

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	~72% Cytotoxicity=25 mg/L	MTS assay	6 h	1
HT-1080	Fibrosarcoma	~84% Cytotoxicity=25 mg/L	MTS assay	6 h	1

Hemolytic Activity The HL50 values of Pardaxin-6 (about 100 mg/L) were much higher than those of EP-1 and EP-9

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00455

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C134H217N29O34

Absent amino acids CDEHMNQRWY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 8

Molecular weight (Average) 2778.37

Molecular weight (Monoisotopic) 2776.61

Common amino acids LS

Net charge 2

Instability index (II) 20.11

Aliphatic index 137.41

Grand average of hydropathicity (GRAVY) 1.259

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23598079

Title Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus

Doi 10.1016/j.peptides.2013.04.004

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available