This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1CEa LK3
General Information
DCTPep ID DCTPep00459
Peptide Name Temporin-1CEa LK3
Sequence FKKLKKIANIINSIFKK
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | IC50=224.8µM | MTT assay | 24h | 1 |
| BCaP-37 | Human papillomavirus-related endocervical adenocarcinoma | IC50=25.04µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=27.72µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: LC50=4649 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00459
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H169N25O21
Absent amino acids CDEGHMPQRTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 3
Molecular weight (Average) 2033.57
Molecular weight (Monoisotopic) 2032.29
Common amino acids K
Net charge 6
Instability index (II) 2.59
Aliphatic index 120.59
Grand average of hydropathicity (GRAVY) -0.118
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23609760
Title Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4540
This work is licensed under a Creative Commons Attribution 4.0 International License.